Tag: management

  • Carbon, metabolism and management

    Uncategorized | Douglas Kell

    Since I had almost no external visits in last week’s Bank Holiday-truncated schedule – although I did have one of my regular 1:1 meetings with Sir Mark Walport of the Wellcome Trust – I shall ruminate a little on the relationships between biochemistry and management. This is partly, of course, because both involve an understanding of systems and how they adapt to external inputs, a rather nice example from this perspective (IMHO) being an analysis that I have just co-authored. As I have remarked before, biological systems have tended to select for robustness over immediate efficiency; one way that this can achieved is via a substantial elasticity of individual biochemical steps to changes in inputs. In the study cited, we looked at the rather extensive changes in gene expression and metabolism consequent upon a pulsed change in nutrient status. Some, such as changes in inosine metabolism, were rather striking and not necessarily expected, which is why it is best not to start with hypotheses for this kind of experiment. [...]